The Scottish Professional Football League has turned down a request from Inverness CT to have Saturday's game at Queen of the South postponed.
The Highlanders suffered significant travel problems following a road traffic accident on the A9.
Caley Thistle say they left Inverness at 13:00 GMT on Friday and only arrived in Dumfries at 03:00 on Saturday.
"The strain and the stress on our players and staff has been terrible," said Inverness manager John Robertson.
"They had to grab food at a service station at midnight as we hadn't eaten since 12:30 on Friday. We had run out of water on the bus by 20:00.
"Our thoughts are with all the families of those involved in the crash and we hope they are all okay."
An SPFL spokesman said there was "some discussion" about the situation but the conclusion was reached that the game should go ahead as scheduled.