Alloa are looking for a second Highland scalp in the League Cup after victory over Ross County in the group stages saw the holders knocked out.
Jim Goodwin returns from suspension for the in-form hosts.
Inverness CT winger Aaron Doran could start for the first time in 13 months following his return from a serious knee injury.
Defender Josh Meekings and second-choice goalkeeper Ryan Esson will return to training later in the week.
Caley Thistle sailed through the group stage of the League Cup but came unstuck at the weekend, opening their Premiership campaign with a 2-0 loss at Partick Thistle.
Alloa have made a flying start to the season, maintaining their 100% record with a 4-0 win at home to Peterhead in League One.
Inverness manager Richie Foran: "Alloa have had a great group stage. "They conceded less goals than us, finished top of their group, and had a great win on Saturday as well, scoring four goals against Peterhead. But I believe in my players."
Alloa boss Jack Ross: "This will be a very difficult game against a full-time side, but I could not have asked any more from the players ahead of it.